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Nicotine can also induce DA release in the prefrontal cortex (PFC) via stimulation of nAChRs located on the cell bodies on DAergic neurons projecting from the VTA to the PFC (George et al , 2000) and via nAChRs in the PFC (Livingstone et al , 2009)

This study has identified smoking as one of those risk factors

Bhatnagar A, Whitsel LP, Blaha MJ, Huffman MD, Krishan-Sarin S, Maa J et al

About 1020% of people who drink alcohol excessively develop cirrhosis of the liver , and there are correlations in a population between rates of liver cirrhosis and mean alcohol consumption

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